Hemophilia and Atherosclerotic Plaque Imaging

Hemophilia and Atherosclerotic Plaque Imaging - Hemophilia and Atherosclerotic Plaques

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46894

Enrollment

Registered

2014-02-06

Start date

2017-11-15

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis hemophilia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Study population:;1. Hemophilia A or B patients 2. Males, 18 years and older 3. Presence of cardiovascular risk factors, including an age of 50 years and more;Controls: 1. Males, 18 years and older 2.. Presence of cardiovascular risk factors, including an age of 50 years and more

Exclusion criteria

Exclusion criteria: Study population and controls: 1. Symptomatic carotid atherosclerotic disease 2. History of allergic reaction to gadolinium (very rare) 3. History of claustrophobia 4. History of severe renal failure (estimated glomerular filtration rate -

Design outcomes

Primary

Measure	Time frame
The primary outcome is the plaque constitution in terms of intraplaque hemorrhage and plaque burden as measured with 3T MRI in both hemophilia patients and patients and controls	—

Secondary

Measure	Time frame
Secondary parameters are differences in endothelial wall function and plaque components (calcification, necrotic core) between the patient and control group. Furthermore, the relation between plaque composition and severity of haemophilia and traditional cardiovascular risk factors will be analysed.	—

Countries

Netherlands

Outcome results