Does Automated closed-loop ventilation Reduce the DRiving Pressure levels in patients with ARDS (AiRDRoP) - an international multi-center crossover study and randomized controlled trial

Does Automated closed-loop ventilation Reduce the DRiving Pressure levels in patients with ARDS (AiRDRoP) - an international multi-center crossover study and randomized controlled trial - AiRDRoP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46892

Enrollment

Registered

2017-04-13

Start date

2017-11-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute lung injury ARDS

Interventions

One group will be ventilated with INTELLiVENT-ASV, the other group will be ventilated with conventional lung protective ventilation. Extra esophageal pressure measurements will be performed.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Moderate/severe ARDS - Intubated and ventilated - Within 24 hours of initial diagnosis of ARDS

Exclusion criteria

Exclusion criteria: - Age

Design outcomes

Primary

Measure	Time frame
Transpulmonary driving pressure	—

Secondary

Measure	Time frame
- End expiratory pressure in the respiratory system - End expiratory pressure in the esophagus - End inspiratory pressure in the respiratory system - End inspiratory pressure in the esophagus - tidal volume (Vt) - positive end-expiratory pressure (PEEP) - plateau pressure (Pplat) - peak pressure (Ppeak) - respiratory rate (RR) - fraction of inspired oxygen (FiO2) - exhaled CO2 (etCO2 en VCO2) - peripheral oxygen saturation (spO2) - CO2 tension in arterial blood (PaCO2) - oxygen tension in arterial blood (PaO2) - oxygen saturation in arterial blood (saO2) - pH of arterial blood - bicarbonate in arterial blood (HCO3)	—

Measure

Time frame

- End expiratory pressure in the respiratory system - End expiratory pressure in the esophagus - End inspiratory pressure in the respiratory system - End inspiratory pressure in the esophagus - tidal volume (Vt) - positive end-expiratory pressure (PEEP) - plateau pressure (Pplat) - peak pressure (Ppeak) - respiratory rate (RR) - fraction of inspired oxygen (FiO2) - exhaled CO2 (etCO2 en VCO2) - peripheral oxygen saturation (spO2) - CO2 tension in arterial blood (PaCO2) - oxygen tension in arterial blood (PaO2) - oxygen saturation in arterial blood (saO2) - pH of arterial blood - bicarbonate in arterial blood (HCO3)

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)