arrhythmia atrial fibrillation palpitations
Conditions
Interventions
All participants will undergo a fluid challenge during the CMR exam with
intravenous administration of 500ml NaCl 0.9%.
Patients with AF will undergo the same fluid challenge during PVI treatment as
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Atrial fibrillation (AF) groups: paroxysmal AF (defined as AF with spontaneous termination within seven days) OR persistent AF (defined as not self-terminating AF lasting more than 7 days, but not permanent AF); scheduled for pulmary vein isolation treatment Healthy controls: No history of cardiac disease
Exclusion criteria
Exclusion criteria: All subjects: age under 18 or greater than 75 years; clinically significant valvular disease; left ventricular ejection fraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome of this study will be the presence of atrial vortex flow, vortex properties, and particle traces in the left atrium as visualized and quantified by 4D flow CMR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will be left atrial fibrosis as detected by CMR and left atrial function derived from combining the volumetric measurements on CMR with invasive pressure measurements acquired during pulmonary vein isolation(PVI) procedure in patients with paroxysmal/persistent AF. | — |
Countries
Netherlands
Outcome results
None listed