post-traumatic stress disorder
Conditions
Interventions
TDCS (1.25 mA, 20 min.) increases neural excitability under the anodal
electrode (here: attached to the scalp over the right inferior frontal gyrus,
rIFG) and decreases neural excitability under the
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Dutch military personnel - Age 18 - 60 years - Presence of problems with aggression regulation according to criteria as described in (Coccaro, 2012) or any anxiety disorder according to DSM-IV criteria except for obsessive-compulsive disorder (OCD) - Receive treatment for above-mentioned symptoms - Provide written informed consent
Exclusion criteria
Exclusion criteria: - Predominant major depressive disorder (MDD) - Alcohol or drug dependence - Severe psychiatric or neurological disorders, e.g., Parkinson*s disease. - Serious head trauma or brain surgery (N.B. TBI without brain damage or skull damage is not a reason for exclusion) - Large or ferromagnetic metal parts in the head (except for a dental wire) - Implanted cardiac pacemaker or neurostimulator - Pregnancy - Concurrent or recent (within previous month) participation in a neuromodulation / neurostimulation (e.g., tDCS, TMS) experiment. - Skin damage or diseases at intended electrode sites (tDCS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the pre-to post-intervention change in inhibitory control on the training task (stop-signal task). | — |
Secondary
| Measure | Time frame |
|---|---|
| Second, we aim to test the pre-to post-intervention changes in symptoms related to anxiety and aggression, threat-related (emotional Go/No-Go task) and implicit inhibitory control (implicit association task). Additionally we look at post-intervention attentional threat avoidance (dot-probe task). Finally, we assess symptom reduction at 3 and 12 months follow-up. | — |
Countries
Netherlands
Outcome results
None listed