Anorexia and satiety
Conditions
Interventions
Patients will be treated with infusion allogenic (feces from femal donor with a
BMI 22-25 kg/m2) microbial transplantation by duodenal tube after bowel lavage.
Bowel lavage is performed by infusion
Anorexia nervosa
Gut microbiota
Satiety
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Recipients: - Caucasian female - Older than 18 years - BMI
Exclusion criteria
Exclusion criteria: Recipients: - Medication use, including PPI and antibiotics in last 3 months - Smoking, XTC, amphetamine or cocaine abuse - Alcohol abuse (>3/day) - A concomitant severe psychiatric disorder, such as psychosis, severe depression or a personality disorder that renders them unsuitable for the trial as judged by a psychiatrist - Participation in a research protocol involving radiation exposure in the last 2 years. - Contraindication MRI (pregnancy, pacemaker and metals contraindicated for MRI). - Cholecystectomy - Expected prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Fecal gut microbiota composition (morning stool samples) - Response to food pictures. The primary outcome is the difference in BOLD signal, i.e. in CNS activation, in predefined regions in the CNS in response to viewing food pictures. - Satiety and Appetite, measured by visual analog scale (VAS), Satiety Labeled Intensity Magnitude (SLIM) scale and plasma markers for satiety and appetite (tryptophan, ghrelin, leptin, neuropeptide Y and orexin levels) upon Mixed Meal Test (MMT). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Energy metabolism, measured by resting energy expenditure (REE) and physical activity energy expenditure (PAEE) - Serotonin levels (platelet/serum serotonin and 24 hour collected urine for 5-HIAA. - Dietary intake (https://mijn.voedingscentrum.nl/nl/eetmeter), weight and body composition (Body Impedance Analysis, BIA). - Psychological response: Score on the Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) and obsessive compulsive symptoms and/or compulsivity about feeding will be measured with the Yale Brown Obsessive Compulsive Scale) - Quality of life (Eating Disorders Quality of Life, EDQOL) and assessment of eating behaviour with the Eating Disorder Inventory (EDI-II) and the Eating Disorder Examination Questionnaire (EDE-Q) and the). | — |
Countries
The Netherlands
Outcome results
None listed