Glucose metabolism
Conditions
Interventions
One group receives daily a dose of 30g of WholeFiber (WF fiber) and the other
group 16g maltodextrin (placebo) for 21 days. Before that time a 2 week run-in
on half the dose wil take place.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male/Female * Age 40-75 yr * Fasting blood glucose between 5.6 and 6.9 mmol/L (pre-diabetes according to American Diabetes Association 2016) * Or fasting blood glucose between 5.0 and 5.6 mmol/L and diabetes risk score (DRS) * 9.
Exclusion criteria
Exclusion criteria: * Having a history of medical or surgical events that may significantly affect the study outcome (IBS or IBD) * Having Diabetes * Medical drug use: for diabetes * Medical drug use: antibiotic use within 3 months of the study start or chronic use of antacids * Mental status that is incompatible with the proper conduct of the study * Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening * Reported slimming or medically prescribed diet * Reported vegetarian, vegan or macrobiotic life-style * Consumption of pre-probiotics or fibre supplements * Sensitive to medical skin adhesives;* Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in fasting insulin and HOMA-ir (a markers of insulin resistance) are the primary outcomes of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in mean glucose and glycemic variability (CGM), body weight, waist circumference, microbiota composition, breath hydrogen and GLP-1/PYY and SCFA are the secondary outcomes. | — |
Countries
Netherlands
Outcome results
None listed