Struma zwelling schildklier
Conditions
Interventions
Radioactive iodine treatment conform local treatment protocols or
hemithyroidectomy with resection of the largest lobe.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with symptomatic goitre - Goitre size larger than 40 ml on one side determined on CT - Patients accept both treatment modalities - TSH between 0,5-5,0 mE/L (euthyroidism) without Thyroid suppletion - Not pregnant or childwish within 64 months after treatment - Able to undergo surgery as well as radioiodine treatment (hoe te definieren) - Able to fill in questionnaires and give Informed Consent - 18 years or older
Exclusion criteria
Exclusion criteria: - Goitre suspicious of malignancy on imaging - Bethesda 5 or 6 cytology - Hyperthyroidism - Previous history of thyroid surgery or radioactive iodine - Not eligible for general anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the reduction of symptoms 12 months after treatment, as measured by a decrease of complaints on self-reported QoL questionnaire (THYRPRO). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are goiter volume as measured on a CT-scan without contrast 1 year after treatment and complications (vocal cords palsy, hypo- or hyperthyroidism. | — |
Countries
Netherlands
Outcome results
None listed