neurodegeneratieve aandoeningen (Alzheimer) cerebral amyloid angiopathy small vessel disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for ICH due to cerebral hypertensive vasculopathy patients:;In order to be eligible to participate, a subject must meet the following criteria: - Intracerebral hemorrhage in the basal ganglia or thalamus in patients with hypertension (defined as known history of hypertension, or on antihypertensive drugs either before or in the chronic phase after ICH). Note: patients with high blood pressure during the period of admission after ICH only without any of the above mentioned criteria will not be included. - Subjects are mentally competent to take a decision on participation. - Written informed consent - Age >55 years;Inclusion criteria for Healthy volunteers - Age >55 years - Subject is in good health as established by medical history, physical examination - MMSE 28 or higher
Exclusion criteria
Exclusion criteria: - Evidence of recent neurological diseases other than hypertensive cerebral vasculopathy e.g. brain tumors, other vascular conditions (e.g. malformations), inflammatory or infectious disease) - Evidence of recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: Validated novel biomarkers for CAA in CSF or blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between body fluid biomarkers and neuropsychological and neuroimaging biomarkers. | — |
Countries
Netherlands
Outcome results
None listed