psychiatrische en neurologische stoornissen Psychiatric or neurological disorders such as schizophrenia and depression
Conditions
Interventions
None listed
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age 18-30 years Right-handed
Exclusion criteria
Exclusion criteria: - History of psychoactive medication (e.g., antidepressants, antipsychotics, amphetamines) - History of substance (ab)use (e.g., smoking, cannabis, XTC) - History of psychiatric/neurological disorders (e.g., depression, epilepsy, ADHD) - Eating or using caffeinated drinks during the period of six hours prior to any of the sessions - Heart-related disorders - Metal objects in or around the body. - Participation in a scientific examination where radiation was used, in the last year - Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates. - In women: positive pregnancy test on the day of the PET/CT scan and lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the regional [18F]DOPA influx (Ki) values, performance on computer tasks (typically accuracy and reaction time), psychophysiological measurements of for example blink rate and pupil dilation, self-reports using questionnaires, and structural & functional MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| See primary study parameters | — |
Countries
Netherlands
Outcome results
None listed