'surgical site infection' 'postoperative wound infection'
Conditions
Interventions
Group 1 receives a single dose of 1g of intravenously administered cefazolin,
30 minutes before surgery and group 2 receives a single dose of 2g of
intravenously administered cefazolin, 30 minutes b
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - >17 years old - Undergoing open surgery of the foot or ankle
Exclusion criteria
Exclusion criteria: - Antibiotic treatment within 7 days before the surgery - An open fracture - A medical history of an allergic reaction to a cephalosporin or severe reaction to penicillin, or any other *-lactam antibiotic - Insufficient comprehension of the Dutch language to understand the patient information to make an informed decision to participate - Kidney disease (eGFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: fT>MIC at the 'target-site' | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome: fT>MIC in serum, rate of SSI, correlation between fT>MIC and infection | — |
Countries
Netherlands
Outcome results
None listed