Healthy volunteer study for development of ASL MR for perfusion imaging of salivary glands

Healthy volunteer study for development of ASL MR for perfusion imaging of salivary glands - Volunteers ASL MR salivary glands

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46769

Enrollment

Registered

2018-06-12

Start date

2018-04-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal perfusion and adaptation thereof to stimuli of the salivary glands.

Interventions

The first 3 scans have no intervention. De last scan will be acquired during stimulation or suppression of salivation (random). Stimulation of salivation is achieved by citric acid, smelling food or

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteer.

Exclusion criteria

Exclusion criteria: Age

Design outcomes

Primary

Measure	Time frame
The semi-quantitative perfusion signal will be measured on ASL MR maps from representative slices of the parotid and submandibular glands. Perfusion will be expressed in mL/min/100g tissue. This will be used to calculate the normal value (median) with confidence interval per gland type. The variation between separate scans will be used to calculate the intra- and inter-day variation.	—

Secondary

Measure	Time frame
The detectability of effects will be estimated based on comparison of baseline scans with intervention scans (stimulation or suppression of salivation).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)