Vascular calcification in renal TransplantLines

Vascular calcification in renal TransplantLines - TransplantLines-CAC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46743

Enrollment

250

Registered

2018-04-16

Start date

2018-06-14

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

niertransplantatie vascular calcification

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Age >=18 years 2. Male and female renal transplant recipients 3. Participant of TransplantLines 4. 6-12 months post kidney transplantation 5. eGFR > 30 ml/min/1.73m2 6. Signed informed consent

Exclusion criteria

Exclusion criteria: 1. Life-expectancy

Design outcomes

Primary

Measure	Time frame
The main study parameter is the association between baseline serum calcification propensity and the relative change in the CAC score over a two-year period.	—

Secondary

Measure	Time frame
To identify endogenous and exogenous determinants of CAC-score (progression) and calcification propensity information on age, sex, medical history, duration of pre transplantation dialysis, lifestyle factors including detailed nutrition data and physical activity, use of medication, physical data (including blood pressure and body mass index), and biochemical data, including blood and 24-h urine samples will be collected as part of routine TransplantLines procedures. From the samples collected and stored by TransplantLines, we will analyse parameters of vitamin K status (e.g., nonphosphorylated-uncarboxylated [dp-uc] MGP), parameters of mineral metabolism (i.e., serum phosphate, calcium, albumin, magnesium, PTH, and FGF23), lipid profile, renal function and albumin excretion/24h.	—

Measure

Time frame

To identify endogenous and exogenous determinants of CAC-score (progression) and calcification propensity information on age, sex, medical history, duration of pre transplantation dialysis, lifestyle factors including detailed nutrition data and physical activity, use of medication, physical data (including blood pressure and body mass index), and biochemical data, including blood and 24-h urine samples will be collected as part of routine TransplantLines procedures. From the samples collected and stored by TransplantLines, we will analyse parameters of vitamin K status (e.g., nonphosphorylated-uncarboxylated [dp-uc] MGP), parameters of mineral metabolism (i.e., serum phosphate, calcium, albumin, magnesium, PTH, and FGF23), lipid profile, renal function and albumin excretion/24h.

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Countries

Netherlands

Outcome results