NIfedipine levels in Mothers with and without PreEclampsia and their Newborns.

NIfedipine levels in Mothers with and without PreEclampsia and their Newborns. - NIMPEN

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46737

Enrollment

Registered

2018-09-28

Start date

2019-03-07

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

for instance preeclampsia hypertensive pregnancy disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - pregnant - prescription of nifedipine - delivery planned in Sophia Children*s hospital - understanding of Dutch / English in speaking and reading - written informed consent

Exclusion criteria

Exclusion criteria: - not unwilling or unable to give written informed consent - multiple pregnancy - infectious diseases (e.g. HIV, hepatitis B, ZIKA) for laboratory safety - fetal congenital abnormalities - manual placenta removal

Design outcomes

Primary

Measure	Time frame
Concordance between the fetal/maternal ratio (both predicted and calculated) between pregnancies without and with hypertension or PE. Since variation is expected to be high, values 1 (fetal accumulation) will be considered as similar between both groups.	—

Secondary

Measure	Time frame
Concordance between the fetal/maternal ratio between the placental perfusion model and the in vivo data. Since variation is expected to be high, values 1 (fetal accumulation) will be considered as similar between both groups.	—

Countries

Netherlands

Outcome results