Insulin resistance obesity overweight
Conditions
Interventions
Participants will perform three regimes of each four days: 1) sitting regime
(sitting 14h/day), 2) exercise regime (sitting 13h/day with cycling 1h/day) and
3) sit less regime (sitting 9h/day, stand
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Caucasian postmenopausal females. Aged 45-70 years at start of the study. Body mass index (BMI) 25 * 35 kg/m2. Stable dietary habits (no weight loss or gain >5kg in the past 3 months) Sedentary lifestyle (not more than 2.5 hours of intensive exercise per week in the past 3 months)
Exclusion criteria
Exclusion criteria: Type 2 diabetes Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other). Alcohol consumption of >2 servings per day. Smoking in the past 6 months. Failed sitless try-out day. Mental or physical disability which interferes with physical activity. Reported participation in night shift work 2 weeks prior to the start of the study and during study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Insulin sensitivity by implementing a 2-step hyperinsulinemic euglycemic clamp | — |
Secondary
| Measure | Time frame |
|---|---|
| * Ex vivo skeletal muscle mitochondrial respiration * Plasma substrate metabolism markers * Plasma cardiometabolic markers * Energy expenditure * Average resting blood pressure over 30 min * Intrahepatic lipid content | — |
Countries
Netherlands
Outcome results
None listed