revalidatie na herseninfarct/bloeding n.a.
Conditions
Interventions
Each participant receives once a dose of Levodopa / Carbidopa (100mg / 25mg)
and once a placebo. The two intake moments are separated for at least a week.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy Male Aged 18-55 years Informed consent obtained
Exclusion criteria
Exclusion criteria: History of neurological or psychiatric disorders History of neurosurgery History of Sleep disorders History or evidence of renal, gastrointestinal, hepatic or hematologic abnormalities Using acute or chronic psychoactive drugs Alcoholism Smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main objective of the study is to determine the role of dopamine on motor learning in healthy individuals. The participants will be subjected to two different cerebellar specific motor adaptation paradigms: the inward saccade adaptation task and the visuomotor adaptation task. The motor learning capacity will be determined by quantifying the velocity and gain of adaptation. The motor timing, motor tremor, motor strength and attention task are control experiments that allow us to put the output parameters of adaptation tasks in the correct perspective. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed