Perifeer Arterieel vaatlijden (vaataandoeningen) claudication
Conditions
Interventions
In a randomized cross-over manner, participants will follow an acute
supplementation protocol in which they will a high nitrate meal in de form of
vegetables and/or ingest 400 mg (6.5 mmol) nitrate
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - stable intermittent claudication for at least three month; - ABI (the ratio of BP in the lower legs to the BP in the arms)
Exclusion criteria
Exclusion criteria: - any condition other than PAD that limits walking; - patients diagnosed with diagnosed with chronic kidney disease and/or or patients with insulin dependent diabetes; - previous endovascular or surgical treatment for claudication within the last 12 months - individuals with critical limb ischemia, who are wheel-chair bound, or who have an above or below-knee amputation; - using dietary nitrate supplements;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter will be exercise tolerance, measured as peak walking time | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise tolerance: * Claudication onset time (COT) and distance (COD) * VO2 Vascular function: * Flow mediated dilation (FMD) * Blood pressure (BP) and heart rate (HR) * Tissue oxygenation (NIRS) Nitrate and nitrite: * Plasma nitrate and nitrite concentrations * Dietary intake | — |
Countries
Netherlands
Outcome results
None listed