Acute lung injury healthy lungs
Conditions
Interventions
Insertion esophageal cathether if not already in place for clinical purposes
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: * Informed consent * Age younger than 12 years * Need for mechanical ventilation for at least 24 hours * Haemodynamically stable, assessed by the attending physician
Exclusion criteria
Exclusion criteria: * No informed consent * Chronic respiratory failure on home ventilation * Intracranial hypertension * Bone marrow transplantation * Immunocompromised patients (congenital or acquired) * Pre-existing pulmonary hypertension * Uncorrected congenital heart disease with left * to * right shunting or cyanotic heart disease * Single ventricle laesions * Evidence of esophageal pathology or the inability to pass a combined esophageal balloon/nasogastric feeding tube * Contraindication to the passage of an esophageal pressure probe by either the oral or nasal route * Withdrawal of life * sustaining treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak-to-through oesophageal pressure at varying amounts of air in balloon | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Peak-to-through oesophageal pressure at varying amounts of air in balloon and body position (supine vs 30° upright) b) Difference in optimal balloon volume between children with and without lung injury | — |
Countries
Netherlands
Outcome results
None listed