Intensive Care zorg Respiratory muscle dysfunction Weakness of the muscles of breathing
Conditions
Interventions
A stepwise inspiratory threshold loading protocol. During this protocol Pdi,
EAdi and other physiological parameters are collected with a dedicated
measurement set-up and stored offline for further
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Informed consent Age *18 years
Exclusion criteria
Exclusion criteria: History of cardiac and/or pulmonary disease Current cardiac and/or pulmonary symptoms History of pneumothorax Contradinication for nasogastric tube placement (recent epistaxis, upper airway surgery, coagulopathy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) To create a model that predicts the relationship between Electrical activity of the diaphragm (uV) andTrans-diaphragmatic pressure (Pdi), calculated as Stomach pressure (Pga) - Esophageal pressure (Pes). 2) Investigate how accurate the predicted Pdi is when calculating the pressure-time product (PTP) and the breath work (WOB) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Investigate to what extent the predicted Pdi values are accurate during fatiguing loads. 2) Examine to what extent and in what order the accessory and expiratory respiratory muscles are recruited during increased work of breathing. | — |
Countries
Netherlands
Outcome results
None listed