cortical correlates of neuropathic pain workingsmechanisms of spinal cord stimulation
Conditions
Interventions
In a double-blind randomized design, patients will receive conventional tonic
SCS, burst SCS and placebo SCS, each for a one-week period. Four MEG sessions
will be performed at baseline and with ton
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: a patient with SCS must meet the following criteria: * Over 18 years, * SCS for at least 3 months, * Stable response to conventional (tonic) stimulation, * Pulse generator suitable for burst stimulation, * Active tip of the implanted electrode at spinal level Th8 or below, * Pulse generator implanted in the lower body, * Capable of participation: travelling to the institute and filling in the questionnaires;a control subject with pain must meet the following criteria: * Over 18 years, * Chronic neuropathic pain in the lower body part, * Preferably on a waiting list for a SCS implant, * Capable of participation: travelling to the institute and filling in the questionnaires.;a control subject without pain must meet the following criteria: * Over 18 years, * No pain or other neurological disease, * Capable of participation: travelling to the institute and filling in the questionnaires.
Exclusion criteria
Exclusion criteria: * Severe pain that is interfering with the pain that the SCS is used for, * Hospitalised or another form of serious decline of general health.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in the power in frequency bands in cortical pain processing areas as well as attention areas under the three stimulation settings. Differences in coherence and frequency coupling within pain processing areas, and between pain processing areas and attention areas. Modulation of evoked responses to peripherally applied electrical stimulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| . | — |
Countries
Netherlands
Outcome results
None listed