The change of red blood cell properties and platelet function over time during extracorporeal life support

The change of red blood cell properties and platelet function over time during extracorporeal life support - RBC ECLS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46661

Enrollment

Registered

2018-05-09

Start date

2018-03-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

red blood cell properties and platelet function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All adult patients who start with ECLS in the ICU

Exclusion criteria

Exclusion criteria: - Pregnancy - Start of ECLS not in the ICU, e.g. after cardiothoracic surgery - Use of ECLS only for high risk procedure like percutaneous cardiac intervention with planned removal of ECLS within 24 hours.

Design outcomes

Primary

Measure	Time frame
Red blood cell aggregation and elongation (deformability) assessed by a laser assisted optical rotational cell analyzer (LORCA) on days 1-3, and within 24 hours after weaning of ECLS.	—

Secondary

Measure	Time frame
Red blood cell aggregation and elongation (deformability) assessed by a LORCA on 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Platelet aggregation assessed by the multiple platelet function analyzer (Multiplate) on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Von Willebrand-factor, free hemoglobin, reticulocytes, and D-dimers on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS.	—

Measure

Time frame

Red blood cell aggregation and elongation (deformability) assessed by a LORCA on 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Platelet aggregation assessed by the multiple platelet function analyzer (Multiplate) on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Von Willebrand-factor, free hemoglobin, reticulocytes, and D-dimers on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS.

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Countries

Netherlands

Outcome results