HKS (Hyperkinetic Syndrome) hyperactivity
Conditions
Interventions
After a 2-week baseline period (regular diet) participants will follow a 5-week
FFD preceded by a 1-week transition period.
Sponsors
Wageningen Universiteit
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Meeting DSM-IV ADHD criteria Male Aged 8 up to and including 10 years Right-handed
Exclusion criteria
Exclusion criteria: Diagnosis Autism Spectrum Disorder Diagnosis Developmental Coordination Disorder Premature birth (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADHD symptoms, measured with validated behavioural questionnaires, in relation to neural activation in the frontal and striatal regions during cognitive tasks measured by functional magnetic resonance imaging (fMRI), abundance of genes encoding phenylalanine and tyrosine metabolism enzymes in the gut microbiota, and peripheral blood levels of phenylalanine and tyrosine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters include the assessment of whole brain neural activation patterns during execution of tasks and functional connectivity at rest, executive functioning, comorbid psychiatric disorders, as well as MGB axis parameters, including taxonomic and functional composition of the gut microbiota, peripheral blood mononuclear cell gene expression, peripheral blood metabolites, peripheral blood protein biomarkers, urine metabolites, and DNA genotype and methylation in buccal cells. | — |
Countries
Netherlands
Outcome results
None listed