The calibrated automated thrombogram as a clinical test for monitoring hypercoagulability in patients with cerebral venous sinus thrombosis.

The calibrated automated thrombogram as a clinical test for monitoring hypercoagulability in patients with cerebral venous sinus thrombosis. - CVST-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46638

Enrollment

Registered

2018-03-08

Start date

2018-05-16

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

venous sinus thrombosis venous stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria patient group: Age above 18 years Male and female Radiologically proven sinus thrombosis in the past 3 years;Inclusion criteria control group: *Inclusion criteria control group Age above 18 years Male and female

Exclusion criteria

Exclusion criteria: Exclusion criteria patient group: Patients with known coagulation disorders Patients with a malignancy Patients on hormonal contraception or who receive other hormonal therapy Current use of oral anticoagulants Incapacitated/ mentally disabled subjects;Exclusion criteria control group: Known coagulation disorders Subjects with known malignancy Use of oral hormonal contraception or other hormonal therapy Current use of oral anticoagulants Incapacitated/disabled subjects*

Design outcomes

Primary

Measure	Time frame
Primary outcomes of the calibrated automated thrombogram are: lag time, time to peak, peak height, endogenous thrombin potential (area under the curve) and peak reduction.	—

Secondary

Measure	Time frame
In addition, determinants which influence the coagulation cascade will be measured (i.e.: PT, aPTT, Thrombintime, Fibrinogen, Prothrombin, Anti-thrombin, Free tissue factor pathway inhibitor (TFPI), TFPI activity, Protein C, Free Protein S, Total Protein S, vWF activity, vWF antigen, FVIII activity, FVIII antigen, FV activity, FVII activity, FXI activity, FX activity, FXI activity, FXII activity, FXIII activity, a2-antiplasmin, PAI-1 activity).	—

Measure

Time frame

In addition, determinants which influence the coagulation cascade will be measured (i.e.: PT, aPTT, Thrombintime, Fibrinogen, Prothrombin, Anti-thrombin, Free tissue factor pathway inhibitor (TFPI), TFPI activity, Protein C, Free Protein S, Total Protein S, vWF activity, vWF antigen, FVIII activity, FVIII antigen, FV activity, FVII activity, FXI activity, FX activity, FXI activity, FXII activity, FXIII activity, a2-antiplasmin, PAI-1 activity).

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Countries

Netherlands

Outcome results