Inspiratory muscle training in patients with nemaline myopathy

Inspiratory muscle training in patients with nemaline myopathy - NEMTRAIN

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46630

Enrollment

Registered

2018-06-13

Start date

2018-10-10

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nemaline myopathy rod myopathy

Interventions

Active IMT consists of 15 minutes of IMT, twice a day, 5 days per week for 8 weeks, at a training workload of 30% of MIP using a resistive inspiratory muscle training device. Sham IMT consists of a

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: * genetically-confirmed nemaline myopathy * informed consent from participant or legal representative

Exclusion criteria

Exclusion criteria: * history of another condition that affects respiratory muscle strength or function (e.g. COPD)*

Design outcomes

Primary

Measure	Time frame
The primary outcome parameter is the change in maximal inspiratory pressure (MIP) after active inspiratory muscle training.	—

Secondary

Measure	Time frame
Several secondary outcome parameters: * Diaphragm ultrasound (thickness, thickening, excursion). * Pulmonary function tests (peak cough flow, forced vital capacity, forced expiratory volume the first second, peak expiratory flow, vital capacity) * Respiratory muscle function tests (sniff nasal inspiratory pressure, maximal expiratory pressure, twitch mouth pressure) * Neurological examination * Maximal voluntary contraction * Rate of muscle relaxation * Mobility: Rivermead mobility index, and Community Balance and Mobility Scale * Falls: Falls efficacy scale and Falls History Questionnaire	—

Measure

Time frame

Several secondary outcome parameters: * Diaphragm ultrasound (thickness, thickening, excursion). * Pulmonary function tests (peak cough flow, forced vital capacity, forced expiratory volume the first second, peak expiratory flow, vital capacity) * Respiratory muscle function tests (sniff nasal inspiratory pressure, maximal expiratory pressure, twitch mouth pressure) * Neurological examination * Maximal voluntary contraction * Rate of muscle relaxation * Mobility: Rivermead mobility index, and Community Balance and Mobility Scale * Falls: Falls efficacy scale and Falls History Questionnaire

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)