bowel movement disorder Severe bowel motility disorder
Conditions
Interventions
All subjects will receive a test meal consisting of a standardized 300-kCal
liquid meal (Nutridrink) with a volume of 200 mL. If oral intake seems not
possible as assessed by the treating gastroente
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Willing to give informed consent Willing to undergo MRI 18 years or older Willing to receive a small-volume test meal either orally or via a nasogastric/duodenal tube Diagnosed with CIPO based on symptoms of intestinal occlusion and findings at antroduodenal manometry compatible with CIPO (abnormal propagation of phase 3 or abnormally low contraction amplitudes)
Exclusion criteria
Exclusion criteria: Being unable to give informed consent Inability to hold breath for 20 seconds Contraindications to undergo MRI (certain neuroclips, pacemaker, claustrophobia, pregnancy) Contraindication for ingredients in the test meal (Nutridrink Juice style apple) Substantial risk of vomiting after intake of the test meal (which cannot be solved by placing a nasogastric or duodenal tube), as assessed by a clinician with experience treating this patient group
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the response of small bowel motility to a food stimulus in CIPO patients, expressed as the ratio between the postprandial motility score and the interdigestive motility score, measured with dynamic MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To evaluate if the oral intake of a small-volume test meal is feasible in CIPO patients or if a nasogastric/duodenal tube is necessary. - To assess if there are differences in interdigestive and postprandial motility values of CIPO patients and healthy volunteers. - To assess if there are differences in motility of CIPO patients with a neurogenic and patients with a myogenic cause of the disease. | — |
Countries
Netherlands
Outcome results
None listed