Development of the cardiac autonomic nervous system in utero

Development of the cardiac autonomic nervous system in utero - FoCUS - Foetal Cardiac aUtonomic nervous System

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46618

Enrollment

Registered

2018-06-07

Start date

2018-06-22

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiale autonome zenuwstelsel cardiac autonomic nervous system

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Pregnant women with: - Age * 18 years - Singleton pregnancy - Low-risk pregnancy

Exclusion criteria

Exclusion criteria: Detected fetal congenital abnormalities Fetal chromosomal abnormalities identified by diagnostic testing Fetal rhythm disturbances during current pregnancy Pre-eclampsia in current pregnancy Fetal growth

Design outcomes

Primary

Measure	Time frame
HRV measurements (representing cANS): o SDNN (standard deviation of all normal-to-normal (N-N) beats (ms) * representing total variability o RMSSD (root mean square of successive differences between N-N beats (ms) * displays vagal control o SDNN/RMSSD ratio * sympatho-vagal balance in time domain o pNN50 * proportion of N-N intervals differing more than 50 ms	—

Secondary

Measure	Time frame
Factors possibly influencing HRV: o mHR * mean fetal heart rate during investigation o Gestational age at time of ultrasound examination o Fetal Gender o Fetal behavior (e.g. (breathing) movements)	—

Countries

Netherlands

Outcome results