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Blood Outgrowth Endothelial Cells (BOECs) to study endothelial metabolic pathophysiology in diabetes patients.

Blood Outgrowth Endothelial Cells (BOECs) to study endothelial metabolic pathophysiology in diabetes patients. - Diabetes induced endothelial metabolic changes.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON46605
Enrollment
100
Registered
2018-06-05
Start date
2018-10-10
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes diabetes mellitus

Interventions

None listed

Sponsors

Leids Universitair Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, the following criteria must be met: - Age 18 years or older. - Prior diagnosis of type 2 diabetes mellitus. - Subject is willing to participate in the study, must be able to give informed consent and the consent must be obtained prior to any study procedure.;Healthy Controls - Age 18 years or older, participants will be age-matched with recruited patients. - Not known with type 2 diabetes mellitus

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Any concurrent illness, disability or clinically significant abnormality that may, as judged by the investigator, affect interpretation. - Non-diabetic renal disease e.g. known polycystic kidney disease. - Prominent renal deterioration (CKD-EPI *60 ml/min/1.73m² ) - Use of LMW heparin and/or immunosuppressive drugs. - Signs of active infection or autoimmune disease, requiring systemic treatment. - A psychiatric, addictive or any disorder that compromises ability to give truly informed consent for participation in this study. - Use of any investigational drug.

Design outcomes

Primary

MeasureTime frame
Cell metabolism, endothelial maturation markers and angiogenic markers.

Secondary

MeasureTime frame
nvt

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)