This study will evaluate the skeletal muscle anabolic response to protein consumption Muscle growth Muscle protein synthesis
Conditions
Interventions
The post-prandial muscle protein synthetic response after ingestion of protein
intake following resistance exercise will be evaluated.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male - Aged 18-35 y inclusive - BMI 18.5 * 27.5 inclus ive - Healthy recreationally active males
Exclusion criteria
Exclusion criteria: - Allergies to milk proteins - Lactose intolerance - Smoking - Diagnosed diabetes - Diagnosed metabolic or intestinal disorders - A history of neuromuscular problems - Arthritic conditions - Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). - Participation in structured progressive (resistance) exercise program - Previous participation in a 13C amino acid tracer study within the last 1 year - Excessive alcohol use (>3 consumptions per day) - Drugs use in the last 3 months (or the test day needs to be scheduled minimal 3 months after last drugs use)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include muscle protein synthesis rates based on mixed muscle and myofibrilar protein bound [U-13C6]-phenylalanine enrichments. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will include plasma amino acid, glucose and insulin concentrations as well as whole-body protein synthesis, breakdown, oxidation, and net balance. | — |
Countries
Netherlands
Outcome results
None listed