Role of intestinal Acetate Production in human Appetite and Insulin Sensitivity

Role of intestinal Acetate Production in human Appetite and Insulin Sensitivity - APRAISE-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46597

Enrollment

Registered

2018-05-03

Start date

2018-07-15

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity and insulin resistance

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Part of HELIUS study and has given permission to be approached for new studies - Stable body weigh (

Exclusion criteria

Exclusion criteria: - Use of corticosteroids, antibiotics and other immunomodulating medication in last 3 months - current XTC, amphetamine, nicotine or cocaïne abuse - Alcohol abuse (>3 units per day) - Contraindication for MRI (pregnancy, neurological illness, malignancy, history of major heart disease, history of major renal disease, breastfeeding, paecmaker and metals contraindicated for MRI present in the body). - Expected prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count

Design outcomes

Primary

Measure	Time frame
- Postprandial plasma SCFA including acetate levels after a standardized mixed meal test - Intestinal microbiota composition (morning stool samples)	—

Secondary

Measure	Time frame
- CNS (fMRI) responses to food pictures. The primary outcome is the difference in BOLD signal, i.e. in CNS activation in predefined regions (insula, striatum, amygdala, OFC and hypothalamus) in response to viewing food pictures or consuming actual food - Postprandial plasma glucose and insulin levels - Fasting plasma SCFA, glucose and insulin levels at baseline - Energy metabolism, measured by resting energy expenditure (REE) - Baseline physical activity energy expenditure (PAEE) - Dietary intake (https://mijn.voedingscentrum.nl/nl/eetmeter), weight and body composition (Body Impedance Analysis, BIA). - Subjective appetite sensations and food intake (VAS questionnaires)	—

Measure

Time frame

- CNS (fMRI) responses to food pictures. The primary outcome is the difference in BOLD signal, i.e. in CNS activation in predefined regions (insula, striatum, amygdala, OFC and hypothalamus) in response to viewing food pictures or consuming actual food - Postprandial plasma glucose and insulin levels - Fasting plasma SCFA, glucose and insulin levels at baseline - Energy metabolism, measured by resting energy expenditure (REE) - Baseline physical activity energy expenditure (PAEE) - Dietary intake (https://mijn.voedingscentrum.nl/nl/eetmeter), weight and body composition (Body Impedance Analysis, BIA). - Subjective appetite sensations and food intake (VAS questionnaires)

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Countries

Netherlands

Outcome results