A randomized clinical trial to assess the effect of repeated remote ischaemic postconditioning on infarct size in patients with an ischaemic stroke

A randomized clinical trial to assess the effect of repeated remote ischaemic postconditioning on infarct size in patients with an ischaemic stroke - Repeated RIPostC

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46558

Enrollment

200

Registered

2017-12-14

Start date

2018-04-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral vascular accident Ischaemic stroke

Interventions

Remote RIPostC: 4 cycles of ischaemia of the arm by inflating a simple blood pressure cuff around the upper arm at 20 mmHg above systolic blood pressure during 5 minutes followed by 5 minutes of rep

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Informed consent Age >18 years Clinically diagnosed ischaemic stroke using the WHO definition for stroke

Exclusion criteria

Exclusion criteria: Unstable vital signs Admitted >24 hours after onset of symptoms Upper extremity injury or edema contra-indicating RIPostC. Mastectomy on both sides

Design outcomes

Primary

Measure	Time frame
Difference in final infarct size between the intervention and control group. Infarct size will be measured using MRI.	—

Secondary

Measure	Time frame
The primary outcome (infarct size) will be linked to our secondary outcomes: Clinical outcome and vascular, immune, and anti-inflammatory pathways.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)