hand dermatitis Hand eczema
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Age >= 18 years and
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • Immunosuppressive or immunomodulatory treatment within the last 2 weeks • UV radiation therapy within 4 weeks before biopsy • Active bacterial, fungal or viral infection of the hands • Other skin diseases of the hands • Mentally incompetent: patient is unable to make important decisions regarding his or her affairs (to be determined by investigator or treating physician) • Proven contact sensitization with clinical relevance to the hands, in which exposure to allergens is not avoided
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the gene expression profile of vesicular endogenous hand eczema (using transcriptome data and validation with quantitative Polymerase Chain Reaction (qPCR)) in non-lesional and early vesicular skin between and within cases and to healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Protein expression: to further explore the findings from transcriptome analysis in immunohistochemistry experiments on skin taken from patients with vesicular endogenous hand eczema and healthy controls. - To compare histologic morphology of vesicular endogenous hand eczema between and within cases and to healthy controls. - To compare microbiome colonization profile between and within cases and to healthy controles. | — |
Countries
Netherlands
Outcome results
None listed