MTB-Exposure: The role of trained versus adaptive immunity following exposure to Mycobacterium tuberculosis

MTB-Exposure: The role of trained versus adaptive immunity following exposure to Mycobacterium tuberculosis - MTB-Exposure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46541

Enrollment

500

Registered

2019-02-12

Start date

2020-02-11

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mycobacterium tuberculosis immunity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18 years and older contact investigation at the Municipal Health Service written informent consent

Exclusion criteria

Exclusion criteria: HIV-positive and immune modulatory medication and -therapy.

Design outcomes

Primary

Measure	Time frame
Main study parameters/endpoints To measure in vitro mycobacterial growth inhibition at time point zero, six weeks and six months. To characterize monocyte and lymphocyte subsets by using Flow cytometry. Parameters of trained innate immunity will be correlated with eventual induction of adaptive immunity and infectious stages.	—

Secondary

Measure	Time frame
Secondary study parameters / endpoints Analysis of DNA methylation.	—

Countries

Netherlands

Outcome results