Validation of CT Angiography and/or Magnetic Resonance Imaging markers for characterization and quantification of atherosclerosis in the carotid arteries by comparison with surgical specimens.

Validation of CT Angiography and/or Magnetic Resonance Imaging markers for characterization and quantification of atherosclerosis in the carotid arteries by comparison with surgical specimens. - Carotid imaging.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46530

Enrollment

150

Registered

2018-07-19

Start date

2018-04-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Patients with cerebrovascular symptoms (TIA, minor stroke) in the last six months * CTA of the carotid arteries (at the Erasmus Medical Center or referring centre) during the last 2 months (CTA is performed for clinical work-up) * Scheduled endarterectomy of a carotid artery * Signed informed consent * At least 18 years old * Patients who have a documented allergy to MRI contrast media are eligible for MRI, but will not undergo a contrast-enhanced scan. Patients with a renal clearance (eGFR)

Exclusion criteria

Exclusion criteria: * Woman who are pregnant or lactating * Patients who are hemodynamically unstable * Having any physical or mental status that interferes with the informed consent procedure * Not being able to remain lying down for at least 40-45 min (e.g. patients with unstable angina, dyspnea at rest, severe pain at rest, severe back pain) * Contraindications for MRI (e.g. claustrophobia) * Metal chip in the ocular bulb identified on X-ray (If a patient affirms to ever have had a metal chip in his eyeball an X-ray will be made to check if it is still present)

Design outcomes

Primary

Measure	Time frame
1) The accuracy of CT Angiography and/or MRI imaging markers of vessel lumen, arterial flow and plaque composition to characterize atherosclerotic plaque in the carotid arteries. 2) The accuracy of CT Angiography and/or MRI to quantify plaque volume and the volume of the different plaque components. 3) Determinants: blood flow parameters. Outcome: to link blood flow parameters to plaque composition and morphology	—

Measure

Time frame

1) The accuracy of CT Angiography and/or MRI imaging markers of vessel lumen, arterial flow and plaque composition to characterize atherosclerotic plaque in the carotid arteries. 2) The accuracy of CT Angiography and/or MRI to quantify plaque volume and the volume of the different plaque components. 3) Determinants: blood flow parameters. Outcome: to link blood flow parameters to plaque composition and morphology

—

Countries

Netherlands

Outcome results