airway stenosis laryngeal stenosis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient: undergone surgical reconstruction for a congenital or acquired laryngeal stenosis between 1994 and 2018( 6-30 years), able to follow instructions during MRI, informed consent by parents and/or patient Volunteer: age between 6 and 30 years, able to follow instructions during MRI, informed consent by parents and/or volunteer
Exclusion criteria
Exclusion criteria: Patient: contra- indications for MRI, inability to undergo MRI, any current lung infection (symptoms of respiratory distress, severe cough, antibiotics for current lung infection), chronic oxygen need, tracheotomy cannula in situ Volunteer: contra- indications for MRI, inability to undergo MRI, any current lung infection (symptoms of respiratory distress, severe cough, antibiotics for current lung infection), chronic oxygen need, co- morbidities of the lungs, airways or vocal cords
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes of this study are the findings on MRI. In the first sub study we will classify post-surgical changes, this will compared to the normal anatomy of the larynx in healthy children. In the second sub study we will quantify the extent and location of fibrosis. Lastly, in the third sub study, we will quantify the mobility of the vocal cords. This will compared to the normal vocal cord mobility as seen in healthy children. | — |
Secondary
| Measure | Time frame |
|---|---|
| The MRI findings from the first and second sub study will be correlated to clinical status. Clinical status will be assessed through health related questionnaires and spirometry. Findings from the third sub study will be correlated to the rate of dysphonia assessed by the Dysphonia Severity Index and voice questionnaires. | — |
Countries
Netherlands
Outcome results
None listed