The effects of aerobic-based exercise on brain vascular function in elderly men

The effects of aerobic-based exercise on brain vascular function in elderly men - Exercise and brain vascular function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46519

Enrollment

Registered

2017-09-20

Start date

2017-12-20

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance Syndrome Metabolic Syndrome Syndrome X

Interventions

Men will follow in randomized order a tightly controlled, progressive, aerobic-based exercise program or no program for eight weeks, separated by a washout period of twelve weeks. Aerobic-based exer

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Aged between 60-70 years - Men - BMI between 25-35 kg/m2 (overweight and slightly obese) - Sedentary (not moderately active for 3 times or more per week) - Fasting plasma glucose

Exclusion criteria

Exclusion criteria: - Women - Current smoker, or smoking cessation

Design outcomes

Primary

Measure	Time frame
At baseline, anthropometric measurements will be first performed and a fasting blood sample will be drawn. After eight weeks, men have to attend two times the research facilities to perform follow-up measurements. The primary endpoint is the difference at follow-up in mean gray matter cerebral blood flow, as assessed by Arterial Spin Labeling, between the aerobic-based exercise and control treatment.	—

Measure

Time frame

At baseline, anthropometric measurements will be first performed and a fasting blood sample will be drawn. After eight weeks, men have to attend two times the research facilities to perform follow-up measurements. The primary endpoint is the difference at follow-up in mean gray matter cerebral blood flow, as assessed by Arterial Spin Labeling, between the aerobic-based exercise and control treatment.

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Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)