Functional and biochemical assessment of liver regeneration after major hepatectomy

Functional and biochemical assessment of liver regeneration after major hepatectomy - FLASH study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46514

Enrollment

Registered

2018-01-19

Start date

2018-02-15

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bile duct tumor colorectal liver metastsasis Liver tumor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Major liver resection (3 or more Couinaud segments) Written informed consent >= 18 years old

Exclusion criteria

Exclusion criteria: Serum bilirubine > 50 µmol/L 'Two-stage' procedures ALPPS procedure Allergy for mebrofenin Pregnant

Design outcomes

Primary

Measure	Time frame
Correlations between the changes in liver function (as measured with hepatobiliary scintigraphy) at day of admission versus postoperative day 5 and the concomitant changes in circulating regeneration biomarkers	—

Secondary

Measure	Time frame
Variability of liver function whithin a patient. Correlation between postoperative changes in liver stiffness and changes in liver function (as measured with hepatobiliary scintigraphy) at day of admission versus postoperative day 5	—

Countries

Netherlands

Outcome results