The effects of positive end-expiratory pressure on the position, length and function of the diaphragm

The effects of positive end-expiratory pressure on the position, length and function of the diaphragm - Effect PEEP on diaphragm

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46488

Enrollment

Registered

2018-02-22

Start date

2018-04-13

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N/A

Interventions

Participants will breathe with different levels of PEEP through a non-invasive ventilation (NIV) face mask. During the first part of the study, a nasogastric tube will be inserted and EMG surface el

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Signed informed consent Age * 18 years

Exclusion criteria

Exclusion criteria: Symptoms relating to respiratory or cardiovascular disease History of pneumothorax or family history of primary pneumothorax Obesity (BMI > 30) Known pregnancy Contraindications for the placement of a nasogastric tube (Upper airwau/esophageal/gastric/mouth or face pathology, nasal bleeding within the last 2 weeks or use of anticoagulants) Contraindictions for MRI (Electrical/metallic implants, claustrophobia, history in metalworking)

Design outcomes

Primary

Measure	Time frame
The first main parameter is the change in the position of the diaphragm during different PEEP levels, as measured with both ultrasound and MRI. The second parameter is the changes in neuro-mechanical efficiency of the diaphragm (ratio between pressure and electrical muscle activity) during different PEEP levels, as measured with a nasogastric catheter. Furthermore, twitch transdiaphragmatic pressures during different PEEP levels, as measured with magnetic stimulation of the phrenic nerves, will be monitored. At last, changes of the diaphragm*s shape and length during different PEEP levels, as measured with MRI will be used.	—

Measure

Time frame

The first main parameter is the change in the position of the diaphragm during different PEEP levels, as measured with both ultrasound and MRI. The second parameter is the changes in neuro-mechanical efficiency of the diaphragm (ratio between pressure and electrical muscle activity) during different PEEP levels, as measured with a nasogastric catheter. Furthermore, twitch transdiaphragmatic pressures during different PEEP levels, as measured with magnetic stimulation of the phrenic nerves, will be monitored. At last, changes of the diaphragm*s shape and length during different PEEP levels, as measured with MRI will be used.

—

Secondary

Measure	Time frame
The secondary study parameters is the difference between diaphragm parameters obtained by ultrasound and parameters obtained by MRI.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)