Cellular Oxygen METabolism (COMET) measurements during cardiopulmonary bypass

Cellular Oxygen METabolism (COMET) measurements during cardiopulmonary bypass - COMET during CPB

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46485

Enrollment

Registered

2018-05-16

Start date

2018-04-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mitochondrial function during CPB

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age > 18 years - Acceptable proficiency of the Dutch language - 37 patients - ASA 2-4 patients, in order to limit the influence of co-morbidities on the mitochondrial function. - Cardiac surgery requiring CPB

Exclusion criteria

Exclusion criteria: - Presence of mitochondrial disease - Pregnancy/ lactation - emergency surgery, - patients with intracardiac shunts

Design outcomes

Primary

Measure	Time frame
- The mitoPO2 and mitoVO2 will be measured perioperatively. The mitoPO2 can be measured continuously with the COMET and will be defined in mmHg. For the mitoVO2 measurements, the local mitochondrial oxygen supply will be blocked by pressure on the skin. The mitoVO2 are then determined by the on-going oxygen usage inside the mitochondria over time. The mitoVO2 is defined as decline in the mitoPO2 over time; mmHg/s. - The tissue oxygen saturation is measured by the INVOSTM and is defined in percentage (%).	—

Measure

Time frame

- The mitoPO2 and mitoVO2 will be measured perioperatively. The mitoPO2 can be measured continuously with the COMET and will be defined in mmHg. For the mitoVO2 measurements, the local mitochondrial oxygen supply will be blocked by pressure on the skin. The mitoVO2 are then determined by the on-going oxygen usage inside the mitochondria over time. The mitoVO2 is defined as decline in the mitoPO2 over time; mmHg/s. - The tissue oxygen saturation is measured by the INVOSTM and is defined in percentage (%).

—

Secondary

Measure	Time frame
- Haematocrit is measured by standard care blood samples before, during and after CPB and is defined in volume percentage of the red blood cells in blood (vol%) - Throughout the operation and the first 24 hours on the ICU standard hemodynamic parameters, such as blood pressure (mmHg), heart rate (bpm), oxygen saturation (%), end tidal CO2 (kPa), temperture (Celsius) are measured and record every minute during the operation and every 15 minutes on the ICU.	—

Measure

Time frame

- Haematocrit is measured by standard care blood samples before, during and after CPB and is defined in volume percentage of the red blood cells in blood (vol%) - Throughout the operation and the first 24 hours on the ICU standard hemodynamic parameters, such as blood pressure (mmHg), heart rate (bpm), oxygen saturation (%), end tidal CO2 (kPa), temperture (Celsius) are measured and record every minute during the operation and every 15 minutes on the ICU.

—

Countries

Netherlands

Outcome results