indirect heeft het onderzoek betrekking tot obesitas body mass index above 30 kg/m2 overweight
Conditions
Interventions
We will measure resting state brain activity and brain reactivity to taste
(chocolate milk) in a hungry state, a 50% sated state and a 100% sated state.
Between scan sessions, participants will be a
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Right handed * Between 18-35 years old at the day of inclusion * Able to understand and speak English fluently or without difficulty * BMI 18.5-27 kg/m2 * Good general health and appetite * Willing to comply with the study procedures * Willing to be informed about incidental findings of pathology and approving of reporting this to your general physician
Exclusion criteria
Exclusion criteria: * Having difficulties with tasting, smelling, swallowing or eating in general. * Women: Being pregnant or breastfeeding or planning to get pregnant in the upcoming half a year * Women: Using a IUD as anti-conceptive (with exception of Mirena IUD) * Suffering from a neurological, endocrine, or eating disorder, gastrointestinal or mental illness or illness of the thyroid gland, respiratory disease or diabetes. * Having a sight (except glasses) or hearing disorder * Having non-removable dental braces (with the exception of dental wire) * Smoking on average one or more cigarettes/cigars a day * Having a history of, or a current alcohol consumption of, drinking on average more than 21 units per week * Not willing to stop using drugs during the study period (from inclusion till test session) * Use of medication that may influence study outcomes * Allergies or intolerance to any ingredient of the test foods (yoghurt, chocolate milk). * Not willing to eat the study foods/drinks because of eating habits or believes. * Followed an energy restricted diet during the last 2 months * Gained or lost 5 kg of body weight over the last half year * Participating in another research study * Employee of Human Nutrition department of Wageningen university * Thesis student or intern at the chair group of Sensory Science and Eating Behaviour Human Nutrition (WUR). * Not having a general practitioner * Intensive exercising more than 8 hours per week * Not willing to be in an MRI scanner * Claustrophobic * Having non-removable metal in or on the body such as piercings, pacemakers, artificial heart valve, metal implants or prostheses. * High restrained eater according to the Dutch Eating Behaviour Questionnaire (men: score>2.9)*. * Low score (* 4, neutral) for liking the test food on a nine point likert scale*;After the training : * Feeling uncomfortable lying in a (dummy) MRI scanner * Using the weight and height as measured the BMI does not fall within the desired range 18.5-27 kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in brain activity in rest and brain reactivity (BOLD response) upon oro-sensory exposure to food, between hungry and 50% and 100% sated states (3 repeated measures). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome of this study is stomach filling (ml) measured by use of MRI at 4 time points (hungry, after drinking till 50% satiation, at the end of the scanning protocol of the 50% sated state, and during the 100% sated state). | — |
Countries
Netherlands
Outcome results
None listed