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Investigating gastric emptying of cow milk in healthy subjects, who either do or do not experience gastro-intestinal discomfort after cow milk ingestion

Investigating gastric emptying of cow milk in healthy subjects, who either do or do not experience gastro-intestinal discomfort after cow milk ingestion - MIlk DIgestion study (MiDi study)

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON46478
Enrollment
30
Registered
2018-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fysiologie Difference in gastric digestion between cow milk consumers that do or do not experience abdominal discomfort

Interventions

Ingestion of 250ml cow milk.

Sponsors

Wageningen Universiteit
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Drinking cow milk (maximum of 200ml/week for those who declare to not drink milk habitually and a minimum of 700ml/week for those who declare to drink milk habitually) Do report/do not report GI discomfort after milk consumption (depending on study group) Not lactose intolerant (tested with lactose breath test) Female BMI:18.5 * 30 kg/m2 Age: 18 - 60 years Healthy (self-reported) Having given informed consent Need to be willing to be informed about incidential findings of pathology

Exclusion criteria

Exclusion criteria: Having a history of medical or surgical events related to the GI tract that may give rise to GI complaints Medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. Medical drug use that influence the GI tract*s microbiom: antibiotic use within 1 months prior to the pre-study screenings day Daily consumption of probiotics Weekly use of laxatives Lactose intolerance (medically diagnosed) and cow milk allergy Reported unexplained weight loss or weight gain of > 5 kg in the month Reported slimming or medically prescribed diet, vegan or macrobiotic life-style Alcohol consumption of more than 14 glasses/week Smoking more than 4 cigarettes a day Being pregnant, having the intention to get pregnant, lactating or being under postmenopausal hormonal treatment Not having a general practitioner Having a contra-indication to MRI scanning

Design outcomes

Primary

MeasureTime frame
Gastric emptying half-time (t50) derived from gastric content (volume in mL) over time.—

Secondary

MeasureTime frame
Subjective GI symptoms, thirst and appetite.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)