n.v.t.
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Caucasian * Healthy (as determined by dependent physician based on medical questionnaire) * Male * Age: 40-75 * Overweight: BMI 25 * 35 kg/m2 * Prediabetic based on one or a combination of the following criteria: o Impaired Glucose Tolerance (IGT): plasma glucose values * 7.8 mmol/l and * 11.1 mmol/l 120 minutes after glucose drink consumption during OGTT in screening. o Impaired Fasting Glucose (IFG): Fasting plasma glucose * 6.1 mmol/l and * 6.9 mmol/l. o Insulin Resistance: glucose clearance rate * 360 ml/kg/min, as determined using OGIS120. o HbA1c of 5.7*6.4%.;* Regular sleeping time (normally 7 * 9h daily) * Stable dietary habits: no weight gain or loss > 3kg in the last three months
Exclusion criteria
Exclusion criteria: * Use of anticoagulants * Fasting plasma glucose * 7.0 mmol/l * Haemoglobin 20 grams alcohol/day * Subjects who do not want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, 1 month prior to the screening visit * Any contra-indication to Magnetic Resonance Imaging (MRI) scanning: o Any implant or prosthesis that is contra-indicated for MRI (e.g. cardiac pacemaker, defibrillator, neural stimulator and other) o Metal containing foreign bodies in the eye or brain o Any other metal containing objects contra-indicated for MRI scanning (e.g. certain prosthetic limbs, certain tattoos or certain permanent eyeliner*) o Claustrophobia o Epilepsy * Any contra-indication to the Equivital telemetric pill: o Known or suspected obstructive disease of the gastrointestinal tract o History of disorders or impairment of the gag reflex o Previous gastrointestinal surgery o Felinization of the esophagus o Hypomotility disorders of the gastro-intestinal tract * Implanted electromedical device * Extreme early bird or extreme night person (score *30 or *70 on MEQ-SA questionnaire, document F1-2) * Heavily varying sleep-wake rhythm * Nightshiftwork during last 3 months * Travel across > 1 time zone in the last 3 months * Engagement in exercise > 2 hours total per week * Significant food allergies/intolerance (seriously hampering study meals) * Participation in another biomedical study within 1 month before the first study visit * Using > 400mg caffeine daily (more than 4 coffee or energy drink) * Smoking * Any acute condition, exacerbation of chronic condition, or medical history that would in the investigator*s opinion interfere with the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main end-point is a day-night variation/rhythm in skeletal muscle mitochondrial function. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are day-night variations/rhythms in whole-body energy metabolism, skeletal muscle mRNA and protein levels and liver triglyceride concentration. | — |
Countries
Netherlands
Outcome results
None listed