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Control of heart rhythm by the brain: the impact of stress-induced reductions in amygdala and hippocampus GABA activity on cardiac electrophysiology (BrainBeatS)

Control of heart rhythm by the brain: the impact of stress-induced reductions in amygdala and hippocampus GABA activity on cardiac electrophysiology (BrainBeatS) - BrainBeatS

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON46454
Enrollment
25
Registered
2018-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stress and the brain sudden cardiac death (SCD)

Interventions

The socially evaluated cold-pressor test (SECPT)

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male - Age 20-35 years - no heart and vascular disease history - no psychiatric disorder history

Exclusion criteria

Exclusion criteria: - General contraindications for MRI (such as claustrophobia) - heart and vascular disease history - psychiatric disorder history

Design outcomes

Primary

MeasureTime frame
o ECG markers of ANS control: heart rate (HR), heart rate variability (HRV) o Concentrations of GABA and glutamate in amygdala and hippocampus—

Secondary

MeasureTime frame
o Stress markers: The State-Trait Anxiety Inventory (STAI), Perceived Stress Reactivity Scale (PRSR), Barratt Impulsiveness Scale (BIS), life event questionnaire, saliva biomarkers of stress (cortisol) and catecholamines (alpha-amylase10), blood pressure o Amygdala and hippocampus connectivity after the SECPT and control condition (fMRI).—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)