The impact of genetic predisposition in pediatric renal cancer: genotypic and phenotypic characterization

The impact of genetic predisposition in pediatric renal cancer: genotypic and phenotypic characterization - WES-KidTs

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46432

Enrollment

120

Registered

2018-03-13

Start date

2018-06-07

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney tumors Renal tumors

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: - All patients diagnosed with and/or treated for a renal tumor in the Princess Máxima Center. - Additional patients with rare renal tumors may be included from the International Society of Pediatric Oncology (SIOP) 2001 database.

Exclusion criteria

Exclusion criteria: - Previously diagnosed cancer predisposition syndrome associated with the renal tumor NB: These patients will not be included in whole exome sequencing, but will be registered in the WES-KidTs database.

Design outcomes

Primary

Measure	Time frame
Frequency of known and novel genetic causes of pediatric renal cancer.	—

Secondary

Measure	Time frame
To structurally document phenotypic characteristics of children with renal cancer, to optimize genetic counseling and surveillance, and contribute to a better detection of pediatric renal cancer predisposition.	—

Countries

Netherlands

Outcome results