glucose control
Conditions
Interventions
Participants will stay in a respiration chamber and will be exposed to bright
light or dim light on different times during the day. Therefore, subjects will
be exposed to 3 different light intensiti
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male or female * Caucasian * Age 40-75 years * BMI 25-35 kg/m2 * Stable weight (+/- 3 kg in the last 3 months) * One of the four criteria for prediabetes: - Impaired fasting glucose (6.1 mM to 6.9 mM) - Blood glucose values 7.8-11.1 mM 2h after glucose drink consumption during OGTT in screening. - Insulin Resistance: glucose clearance rate * 360 ml/kg/min, as determined using OGIS120. - HbA1c of 5.7*6.4%.
Exclusion criteria
Exclusion criteria: * Fasting plasma glucose *7.0 mM * Any medical condition and/or medication that might interfere with the investigated parameters as judged by study physician. * Unstable body weight (+/- 3 kg in the last 3 months) * Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study. * Blood donation one month prior to study and three months after finishing study. * Participants with extreme chronotypes (going to bed extremely late/early).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is postprandial glucose measured every 30 minutes during 4 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| * Fasting glucose levels * Plasma metabolites (i.e. FFA, TGA, insulin) * 24 hour continuous glucose monitoring * 24 hour energy expenditure * Core body temperature and skin temperature * Subjective perception of thermal sensation and comfort, visual comfort, hunger and satiety, sleepiness | — |
Countries
Netherlands
Outcome results
None listed