subjective effects, cognitive functioning Performance and mood enhancement in society
Conditions
Interventions
Placebo and 5, 10, 20 µg of LSD in randomized order.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Previous experience with a psychedelic drug, but not within the past 3 months. * Proficient knowledge of the English language * Written Informed Consent * Understanding the procedures and the risks associated with the study. * Age between 18 and 40 years * Absence of any major medical condition as determined by medical examination and laboratory analysis * Absence of any major psychological condition as determined by medical examination * Free from psychotropic medication * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. * Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) * Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) * Pregnancy or lactation * Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg) * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) * Psychotic disorder in first-degree relatives * Any chronic or acute medical condition * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*) * For women: no use of a reliable contraceptive * Tobacco smoking (>20 per day) * Excessive drinking (>20 alcoholic consumptions per week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study hypothesis is that higher doses of LSD will be associated with increasingly greater and potentially also qualitatively different subjective effects compared to placebo. An additional study parameter is the change in cognitive performance under the influence of LSD compared to placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to characterize the dose-response relationship in LSD-induced changes in cognitive performance. | — |
Countries
Netherlands
Outcome results
None listed