bloeddruk, elektrolyten, cortison/cortisol balans High bloodpressure hypertension
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Willing and able to participate in the study protocol - Written informed consent - Age 18-60 years - Office diastolic blood pressure maximal 90 mmHg and office systolic blood pressure maximal 140 mmHg - BMI > 18 or
Exclusion criteria
Exclusion criteria: - Allergy to one of the ingredients of licorice - Office blood pressure >140/90 mm - Reported alcohol consumption > 28 units/week or recreational drug use - Existing cardiovascular diseases - Use of medication which affects the primary or secondary outcome measurements such as diuretics, antihypertensive drugs and NSAIDs 200 gr/week) or >3 litre of licorice tea per week - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the difference in 24-hour ambulatory systolic and diastolic blood pressure after exposure to a fixed dose of licorice | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome parameters will be the difference in cortisol/cortisone ratio, potassium, sodium and aldosterone excretion in 24h urine collection. Furthermore, the difference in concentrations of plasma potassium, sodium, eGFR, creatinine, aldosterone and plasma renin activity will be measured. In addition, we will determine the individual weight at the end of the run-in period (screening) and at the end of the intervention period. Finally, an exploratory analysis for single nucleotide polymorphisms in the gene encoding for 11-beta-hydroxysteroiddehydrogenase will be performed in those five participants with the greatest increase in blood pressure | — |
Countries
Netherlands
Outcome results
None listed