inflammatory skin diseases (atopic dermatitis and psoriasis) and genodermatoses (skin diseases caused by genetic disorder)
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients that suffer from atopic dermatitis, psoriasis and genodermatoses
Exclusion criteria
Exclusion criteria: If it is likely that patients develop hypertrophic scars (patients are asked if they do/don't heal nicely after damage to the skin).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * The outcome measures of the cell culture experiments include: morphology of the epidermis and gene expression of the epidermal cells, following stimulation of the cells (e.g. by cytokines or microbes). Gene expression analysis will generate quantitative data (delta Ct of qPCR). * Histology will be scored semi quantitatively (stain intensity and localization). * We will identify relevant mutations of risk genes for psoriasis and AD. In case of genodermatoses, the causative genes are in general already known. * The effect of diagnosis and genotype on gene expression and histology will be analysed with multivariate techniques. | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
Netherlands
Outcome results
None listed