gum disease periodontitis
Conditions
Interventions
The intervention will be the daily intake of vitamin C with flavonoids
supplements (capsules) (test group 1), or vitamin C only supplements (capsules)
(test group 2), compared to a negative control
Sponsors
Universiteit van Amsterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - age: >=18 years; - proximal bone loss of > 3mm in 2 non-adjacent teeth, - probing pocket depth > 3 mm and bleeding on probing on at least 25% of their total sites and documented radiographic bone loss, - good general health.
Exclusion criteria
Exclusion criteria: - diagnosis of any acute periodontal problem which requires immediate treatment; - use of antibiotics within the previous 6 months; - pregnant or lactating women; - previous initial periodontal treatment within the last year; - current orthodontic treatment; - use of any medication which may interfere with quercetin, or with the study outcomes.* - current daily use of supplements containing vitamin C - patients who have had immunotherapy (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical measurements: bleeding on pocket probing (bop), | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical measurements: probing pocket depth (ppd), clinical attachment level (cal), gingival recessions (rec), plaque (plq), tooth mobility (mob), pocket suppuration (sup). Lab variables: Subgingival microbiological profile (analyses by 16S rRNA gene amplicon sequencing by Illumina Miseq platform), Systemic biomarkers HbA1C, hs-CRP, and vitamin C (from venous blood). high density lipids (hdl) low density lipids (ldl) creatinine (crea) triglycerides (trigl) General measurements: Body mass index (bmi) Waist circumference (wc) Bloodpressure (bp) | — |
Countries
Netherlands
Outcome results
None listed