brain tumour Glioblastoma
Conditions
Interventions
Single fraction preoperative radiotherapy.
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * 18 years or older * Newly diagnosed GBM (based on MRI imaging or biopsy) * Ability to undergo standard treatment consisting of (chemo)radiation and surgery (i.e. KPS > 70, indication that more than 70% of the tumor can be removed) * Neuro-oncology multidisciplinary team consensus to include the patient for the current study * Signed written informed consent
Exclusion criteria
Exclusion criteria: * Prior or second invasive malignancy, except non-melanoma skin cancer, completely resected cervical or prostate cancer (with PSA of less than or equal to 0.1 ng/ml) * Suspicion of primary tumor on CT thorax/abdomen in case no biopsy is available * Inability to secure a *coldspot* in the tumor (volume of 2 cc of the contrast enhancing tumor that should not receive irradiation dose, see Chapter 2 and 4) * Inability to secure radiotherapy dose constraints for organs at risk for either the neoadjuvant stereotactic radiosurgery or adjuvant fractionated radiotherapy (see Chapter 2 and 4)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * maximum tolerated dose (MTD) * maximum tolerated irradiated volume (MTIV) | — |
Secondary
| Measure | Time frame |
|---|---|
| * Registration of postoperative surgical complications. * Progression free survival. * Overall survival. | — |
Countries
Netherlands
Outcome results
None listed