Acute pancreatitis
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients In order to be eligible to participate in this study, a subject must meet all of the following criteria: Suspected acute biliary, alcoholic or idiopathic pancreatitis At least 2 out of 3 criteria of acute pancreatitis: - Pain in upper abdomen - Serum amylase and/or lipase >3x upper limit of normal (ULN) - Signs of acute pancreatitis on CT or MR * 18 years old Provide informed consent;Healthy volunteers A person is eligible to participate as healthy volunteer if they are considered to be healthy and if their age and gender matches with a patient included in this study.
Exclusion criteria
Exclusion criteria: Use of medications with possible immune-modulating effects (e.g., steroids or recent chemotherapy) Time from onset of abdominal pain to hospital admission >48 hours Established diagnosis of chronic pancreatitis Suspected cholangitis;Healthy volunteers Use of medications with possible immune-modulating effects (e.g., steroids or recent chemotherapy) Current or recent (in the last two weeks) infectious disease (i.e. influenza) Systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are immune subsets which consist of a clustering of peripheral blood leukocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include serum urea, CRP, leukocyte counts, mortality, morbidity, days of admission, prognostic scores, medical history, medication, alcohol and drug use. | — |
Countries
Netherlands
Outcome results
None listed