nicotine dependence Addiction Nicotine Dependence
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Experimental smokers 1) Smoked 5-500 cigarettes lifetime 2) Smoked in the last 6 months 3) Never smoked on a daily basis;Controls 1) Never smoked a complete cigarette;All participants 1) Age 12-18
Exclusion criteria
Exclusion criteria: All participants 1) Use of psychoactive medication that cannot be stopped for 24 hours before scanning 2) fMRI contraindications 3) A history of neurological disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter for RQ1 is the number of smoked cigarettes per day at baseline, 6, and 12-month follow-up. The main study parameter for RQ2 is brain activation in the ventral and dorsal striatum in response to smoking cues at baseline and at 1-year follow-up. Inclusion of participants will end when the planned number of participants finished the first EMA and baseline measurements. The study will end when the planned number of participants finished all study procedures. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Fagerström test for Nicotine Dependence (FTND) to measure nicotine dependence. - Hooked on nicotine checklist (HONC) to measure the development of symptoms of nicotine dependence. - The Autonomy Over Tobacco Scale (AOTS) to assess autonomy over smoking and cue-induced craving. - Self - Report Habit Index (SRHI) to measure habit behaviour regarding smoking. - Pleasure of smoking questionnaire (PSQ) to measure to which extend participants experience pleasure from smoking. - Task performance on tthe digit span test and the Two-Step task | — |
Countries
Netherlands
Outcome results
None listed